Mediterranean Spotted Fever: Treatment

By | September 27, 2008 | 0 Comments

Mediterranean Spotted Fever also known as Boutonneuse Fever. It is caused by   Rickettsia conorii. It is prevalent in southern Europe, Africa, and southwestern and south-central Asia. Regional names for the disease caused by this organism include Mediterranean spotted fever, Indian tick typhus, Israeli spotted fever, Kenya tick typhus, and Astrakhan spotted fever.

 The symptoms include headache, fever, eschar(tache noire), and regional lymphadenopathy. It is characterized by high fever, rash, and an inoculation eschar at the site of the tick bite. In patients with diabetes, alcoholism, or heart failure the disease can be very severe and mortality is as high as 50% in these patients.

Mediterranean Spotted Fever is diagnosed mainly by clinical findings in the areas where it is endemic and is confirmed by serology, immunohistochemical demonstration of rickettsia in skin biopsy and cell culture & isolation of rickettsia.

  Treatment: The drug of choice for the treatment of Mediterranean Spotted Fever is doxycycline and ciprofloxacin. Doxycycline is given 100 mg orally two times a day for 1-5 days depending on severity. Ciprofloxacin is given 750 mg orally two times a day for 5 days. Other drug which can be used is chloramphenicol 500 mg orally four times per day for 7-10 days.

In mildly ill children clarithromycin or azithromycin can be used successfully. But these are not very successful for treatment of adults. These two drugs are also not useful in severely ill pediatric patients.

You must be logged in to post a comment.